Programme
BOOK OF ABSTRACTS14.00-15.00 Registration 15.00-15.30 Opening and Welcome
Introduction to the XI Paul Ehrlich Euro-PhD network meeting
J. I. Borrell (IQS School of Engineering, Universitat Ramon Llull)
Welcome greeting from the authorities
J. A. Rom Vice-Rector for Research and Innovation, Universitat Ramon Llull
J. Diaz Dean of IQS School of Engineering
S. van Calenbergh Coordinator of the Paul Ehrlich Network15.30-16.00 PLENARY LECTURE 1
From enzyme inhibition to degradation: MMPs, CK and HDAC as anticancer targets
B. de Pascual-Teresa (Professor of Organic and Pharmaceutical Chemistry, Universidad San Pablo CEU)
President of the Spanish Society of Medicinal Chemistry (SEQT16.00-19.00 SESSION A
Mini-Symposium Cancer
16.00-16.30 Invited Lecture A
Tackling oncogenic signaling and tumor-stroma crosstalk in aggressive B-cell lymphoma
G. Roué (Lymphoma Translational lab, Josep Carreras Leukaemia Research Institute (IJC))16.30 Flash Posters in 2 min (FP-1 --> FP-12) 17.00 Coffee break and Poster Session A 17.45 OC-A1/ R. Listro Towards the identification of novel compounds targeting HuR ̶ RNA complexes 18.00 OC-A2/ D. Secci Molecular hybrids as a valid strategy to modulate carbonic anhydrase isozyme inhibitors selectivity 18.15 OC-A3/ C. Cimino Haloperidol metabolite II Valproate ester-loaded NLC as promising strategy for the treatment of Uveal Melanoma 18.30 OC-A4/ J. Ceramella Anti-melanoma and antioxidant properties of Annona cherimola Mill. leaves extracts 18.45 OC-A5/ R. Cosialls PET imaging of self-assembled 18F-labelled Pd2L4 metallacages for anticancer drug delivery 19:00-21:00 Welcome Party - Cloister of the Casa d’Exercicis dels Jesuïtes 9.00-9.30 PLENARY LECTURE 2
Another awakening: Discovering a new drug for narcolepsy
Y. Auberson (Executive Director in Global Discovery Chemistry, Novartis Institutes for BioMedical Research)
Past President of the European Federation for Medicinal Chemistry and Chemical Biology (EFMC)9.30-12.30 SESSION B
Mini-Symposium Anti-infectives
9.30-10.00 Invited Lecture B
Pan-antiviral strategies: the future ahead
N. Izquierdo (Pathogen Immunity, Signaling and Therapeutic Applications, IRSI Caixa)10.00-10.30 Flash Posters in 2 min (FP-13 --> FP-32) 10.30 Coffee break and Poster Session B 11.15 OC-B1/ Martina Pacetti Cycloheptathiophene-3-carboxamides exert potent anti-influenza activity by interfering with polymerase PA-PB1 heterodimerization 11:30 OC-B2/ Silvia Cammarone Resorc[4]arene-functionalized MWCNTs for the development of high selective and sensitive immunosensors 11:45 OC-B3/ Roberta Bivacqua In silico approaches for the identification of HSV-1 Glycoprotein D inhibitors 12:00 OC-B4/ Bárbara Nunes Antibacterial activity of ionic liquids against Staphylococcus aureus 12:15 OC-B5/ Leticia Manén Looking for new anti-malarial drugs in the Tafenoquine Chemical Space: the Markush Dilemma. 12.30-13.00 Keynote
mRNA vaccines beyond Covid19
R. Magaña Group of Materials Engineering, Gemat, IQS School of Engineering13.00-14.30 Lunch IQS Bar-Restaurant 14.30-15.30 Meeting of PE Coordinators and Free Time 15.30-18.30 SESSION C
Mini-Symposium Other Diseases
15.30-16.00 Invited Lecture C
Harnessing multi-target drug discovery for neurodegeneration
M. L. Bolognesi (Professor of Medicinal Chemistry, Università di Bologna)16.00 OC-C1/ Rosa Purgatorio Synthesis and biological evaluation of novel piperazine-
containing selective BChE inhibitors as potential multimodal neuroprotective agents for
Alzheimer's disease16.15 OC-C2/ Emanuela Berrino Carbon Monoxide Releasing Molecular Hybrids: Synthesis
and Biological Evaluation of New Potent Anti-Inflammatory Agents16.30 Flash Posters in 2 min (FP-33 -> FP-44) 17.00 Coffee break and Poster Session A 17.45 OC-C3/ Rebecca Appiani Pyrrolidinyl benzofurans and benzodioxanes: Selective α4β2
nAChR ligands with different activity profiles at the two receptor stoichiometries18.00 OC-C4/ Agata Zięba The 3D-QSAR studies aimed to assist the development of novel
multi-target 5-HT2A/D2 receptor ligands18.15 OC-C5/ Raul Ondoño Novel MD-based drug candidates against DM1 toxic ncRNA 18.30 Social Program - Visit To MNAC and dinner at Hotel La Florida 9.30-10.30 PLENARY LECTURE 3
Going with the Flow – The Use of Continuous Processing for Making APIs
C. Oliver Kappe (Professor of Chemistry, University of Graz)10.30-11.00 Coffee break 11.00-13.00 Presentation of the SEQT B. Pascual-Teresa
PE MedChem Euro-PhD Label communications
PEA-1/ A. Coricello Natural products in drug discovery. In Silico approaches for the detection of new hits against unexplored molecular targets
PEA-2/ M.G. Nizi Discovery of potent and selective PARP inhibitors as valuable phar-macological tools
PEA-3/ M. Rullo MAO B—centered multitargeting ligands against neurodegenerative disorders
PEA-4/ M. Barreca Insight on pyrrole[1,2]oxazole derivatives in multiple lymphoma subtypes
PEA-5/ S. Mirabile Structure- and Ligand-based optimization of fragment binding
Awards Ceremony13.00-13.30 CLOSING REMARKS
J. I. Borrell (IQS School of Engineering, Universitat Ramon Llull)
